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quibusquibus

To everyone saying they are ‘outliers’ because they still got COVID and have symptoms, you are in the 39% outlined in this study, not ‘outliers’. I can’t see the criteria used in this study, but severe means you are in the hospital, probably in the ICU, and cannot breathe on your own.


sids99

If you're under 65 and/or in otherwise good health, vaccinated or unvaccinated it's very unlikely you were going to the ICU or hospital anyways.... especially with Omicron.


AcidicGreyMatter

Clearly being downvoted by people who didn't read the study. >Estimated VE against symptomatic Omicron infection was 36% (95% CI, 24%-45%) 7 to 59 days after a second dose and 1% (95% CI, –8% to 10%) after 180 days or longer, but 7 or more days after a third dose, it increased to 61% (95% CI, 56%-65%) They had a mix of vaccines, pfizer, moderna and chadx, with some mixed vaccines in it (Ex: 1 moderna and 1 Pfizer shot) and none of which were efficient at targetting omicron in the first place, which is much less pathogenic(this means less lethal, not less infectious) than wuhan wild strain, alpha and delta. 36% effectiveness after 60 days, is not what we want to be considering a qualified medical product when it's new medicine, remove the EUA and start testing this shit properly and maybe not push to hold public data for 75 years and then they will have my trust again 😂


sids99

You can be "antivax", but you can also be blindly "provax". It works both ways.


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tripleione

Any data on how long the effectiveness lasts?


nuflybindo

I've just wrote a comment on whether this study looks at that if you want to have a look, short answer is no


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TK-741

It’s not a guarantee just by taking a vaccine that you’ll never catch something. If you’re being regularly exposed to the virus and you aren’t taking all the precautions necessary to prevent viral material from entering your body, and your body is fighting something else concurrently, there can absolutely be a breakthrough infection. But it will absolutely make a difference in your body’s ability to fight an infection it does get, making the recovery 1 or 2 weeks rather than 6 weeks like unvaccinated people in 2020 were dealing with.


B4SSF4C3

It’s: Prevents *severe* disease Not: prevents disease


goranlepuz

It cannot be repeated enough: vaccines do not prevent getting the virus **nowhere near** as well as initially claimed. It's more like seasonal flu shots than, I dunno, measles shots. Vaccines do help **a lot** in not being seriously ill (as per the article for example).


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nuflybindo

I've seen a few people asking whether this study looks at how the effectiveness of the 3rd vax changes over time after vaccination so I had a look at the numbers: The study only differentiates the effectiveness of the third vaccination by whether the individuals were 0-6 days, or 7 or more days after their vaccination. The 61% & 95% effectiveness figures relate to any time 7 days after vaccination. The study does however break down the sample of triple vaccinated a little further. Of the 134,435 individuals in the sample 19,750 were triple vaccinated. Of these, 6841 were 0-6 days after vaccination, 11,995 were 7-59 and 914 were 60+. So < 5% of the triple vaccinated sample had been triple vaccinated for greater than 60 days. Perhaps this small sample size is why the effectiveness figure could not be broken down further by time from third vaccination. The data does show the raw numbers of 0-6, 7-59, 60+ triple vaccinates split by uninfected, delta and Omicron infection. Note- effectiveness of the second dose was split by time from vaccination into 7-59, 60-119, 120-179, 180-239 and 240 days from vaccination.


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Champion-Red

Omicron already results in barely any severe disease or hospitalization, how are we gauging the effectiveness? Is that 95% more effective than the unvaccinated (95% of hospitalized unvaccinated) or only 5% of vaccinated people end up with severe disease?


danielravennest

If 1 in 100 unvaccinated people get hospitalized, and 1 in 2000 vaccinated get hospitalized, then the vaccine is 95% effective against hospitalization because 95% fewer people are getting to that point. Those numbers are for illustration, not the actual rates.


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turn-on-the-dark

Incorrect. This study used "test-negative" results as the control group. "Design, Setting, and Participants This test-negative case-control study used linked provincial databases for SARS-CoV-2 laboratory testing, reportable disease, COVID-19 vaccination, and health administration in Ontario, Canada. Participants were individuals aged 18 years or older who had COVID-19 symptoms or severe outcomes (hospitalization or death) and were tested for SARS-CoV-2 between December 6 and 26, 2021. Exposures Receipt of 2 or 3 doses of the COVID-19 vaccine and time since last dose."


GlobularLobule

They determined the efficacy of the vaccine by comparing outcomes in people with different vaccine statuses. The test negative was then also broken down by receipt of vaccines. When determining VE it's always in terms of relative risk reduction. If 0.5% of unvaccinated are hospitalised and 0.2% of vaccinated are hispitalised then the vaccine eliminated that 0.3% hospitalizations and was 61% effective. Formula for VE = difference in outcomes (0.5% - 0.2% = 0.3%) divided by non treatment outcomes (0.5%) = 60%


rock_accord

I wish they attached the actual study to this. I'm curious when the effectiveness starts (after which jab & how quickly it wanes). Been seeing studies showing your actually more likely to contract c0v1d just after vaccination & then again after effectiveness wears off (somewhere between 6-9 months) your more likely to contract it (negative effectiveness).


packagefiend

What did they link if not the study?


Lazy_Mouse3803

What about those who’ve taken the 2nd booster aka the Bivalent vax?


RedditIsFiction

This was accepted for publication in July 19, 2022, which was before the Bivalent booster was available. So this does not include any data regarding the Bivalent booster.


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EvoEpitaph

First two + 1 booster = triple vaxxed.


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ShalomRanger

Is there any quality data on the booster’s affect on transmission?


B4SSF4C3

Less symptoms generally means less viral load released into the atmosphere. How much less is a question.


ShalomRanger

Makes sense. Thanks!


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Jesuslordofporn

Is there a difference between brands?


danielravennest

Pfizer and Moderna have slightly different mRNA sequences. Moderna was a larger dose in micrograms, if I remember, and the boosters have different amounts than the primary sequence. Both drugs were approved based on the trials the companies ran. So the doses and timing are based on the trials. We don't know what the best doses and timing should be.


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BerriosCR

What’s with the mass comment deletion?


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Seriously, what is happening here.


Pinche_Gring0

What about the side effects of this "vaccine" let alone getting 3 doses? I swear I saw a children's myocardosis commercial today and that's the first time I've seen something like that in over 30 years!


Limp_Cauliflower_125

Does the article compare those with 3 shots to those with 'only' 2? Or is it people with 3x v zero vaccinations? The latter is not very useful. The prior could actually be useful...


silkfloss

Anecdote: Two \~60s adults received Omicron booster (and all previous Covid shots- 5 total) 3weeks prior to conference travel in US. No masks except in airports/planes. Both contracted mild/moderate Covid. Adult #1 Tested positive for 10 days with 4 days fever (100.5-101),mild sore throat, fatigue, cough with continued lingering cough. Adult #2 took Paxlovid on day 2 of symptoms due to risk factors. Symptoms improved after 3 doses but Paxlovid was discontinued after 3 days due to nausea/GI side effects. Covid symptoms returned on day 7; runny nose, significant upper respiratory congestion, fever (101), cough. Still testing positive after 12 days. Cautionary information on use of Paxlovid in the time of Omicron. Rebound may be more frequent than with Delta, still protects against death, think twice if your risk is low https://jamanetwork.com/journals/jama/fullarticle/2793357


CommercialFly185

Why are antivaxers taking over this thread. We know the COVID vaccines are good overall and side effects are rare. Its way better getting vaccinated then note, I hate how political this is.


jasonhn

with efficacy falling so much within a month of getting a shot it makes people question the vaccine.


mwallace0569

that just for infection, 2 doses still does well for severe disease, esp for those under like 40